N)?h ) ael 28 mar, 2914

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Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts. The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online.

Clicking on the donut icon will load a page at altmetric. Find more information on the Altmetric Attention Score and how the score is calculated. Atomistic simulation techniques have been employed to investigate the effect of molecular adsorption of water on the low-index surfaces of calcite, aragonite, and vaterite.

Calculated surface and hydration energies agree with experiment and previous calculations where available.

n)?h ) ael 28 mar, 2914

Known experimental surface features are reproduced, i. Surface carbonate groups tend to rotate to lie flat in the surface. The morphologies of the hydrated crystals agree with experimentally found morphologies. The bulk lattice energies of the polymorphs reflect their thermodynamic stability. Corresponding author. B, 16 View Author Information. Cite this: J. B, 16— Article Views Altmetric.

Citations Abstract Atomistic simulation techniques have been employed to investigate the effect of molecular adsorption of water on the low-index surfaces of calcite, aragonite, and vaterite. Cited By.

This article is cited by publications. ACS Omega5 20 ACS Omega5 2 Koskamp, Sergio E. De Leeuw, Mariette Wolthers.Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

A Nature Research Journal. The basic unit of skeletal muscle in all metazoans is the multinucleate myofibre, within which individual nuclei are regularly positioned 1. The molecular machinery responsible for myonuclear positioning is not known. Improperly positioned nuclei are a hallmark of numerous diseases of muscle 2including centronuclear myopathies 3but it is unclear whether correct nuclear positioning is necessary for muscle function.

We find that these proteins interact physically and that expression of the Kif5b motor domain fused to the MAP7 microtubule-binding domain rescues nuclear positioning defects in MAP7-depleted cells. This suggests that MAP7 links Kif5b to the microtubule cytoskeleton to promote nuclear positioning. Finally, we show that myonuclear positioning is physiologically important.

Drosophila ens mutant larvae have decreased locomotion and incorrect myonuclear positioning, and these phenotypes are rescued by muscle-specific expression of Ens.

We conclude that improper nuclear positioning contributes to muscle dysfunction in a cell-autonomous fashion. Bruusgaard, J. Number and spatial distribution of nuclei in the muscle fibres of normal mice studied in vivo.

Cohn, R. Molecular basis of muscular dystrophies. Muscle Nerve 23— Jungbluth, H. Centronuclear myotubular myopathy.

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n)?h ) ael 28 mar, 2914

Tablafina is now open in Barcelona. A unique gastronomic concept by Abel Valverde with designation of origin, connecting nature and local products. There are no rooms available that meet your search criteria.

Air conditioning - Climate Control. There are plenty of bars and restaurants on the doorstep, and the city center is just 15 minutes away. The building itself is an avant-garde creation by the famous Spanish architect Rafael Moneo.

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2014-2016 Ebola Outbreak in West Africa

Contact us Central See all phone numbers.The Ebola outbreak in West Africa has ended. Visit the Ebola Outbreak section for information on current Ebola outbreaks. The identification of these early cases marked the beginning of the West Africa Ebola epidemic, the largest in history. The initial case, or index patient, was reported in December An month-old boy from a small village in Guinea is believed to have been infected by bats.

n)?h ) ael 28 mar, 2914

After five additional cases of fatal diarrhea occurred in that area, an official medical alert was issued on January 24,to the district health officials. By Julythe outbreak spread to the capitals of all three countries. This was the first time EVD extended out from more isolated, rural areas and into densely populated urban centers, providing an unprecedented opportunity for transmission. Later secondary infection, mainly in a healthcare setting, occurred in Italy, Mali, Nigeria, and the United States.

The scope of this outbreak, both in terms of cases and geography, can be attributed to the unprecedented circulation of EVD into crowded urban areas, increased mobilization across borders, and conflicts between key infection control practices and prevailing cultural and traditional practices in West Africa. Engaging local leaders in prevention programs and messaging, along with careful policy implementation at the national and global level, helped to eventually contain the spread of the virus and put an end to this outbreak.

Liberia was first declared Ebola-free in May Additional cases were found and treated, and the country was again declared Ebola-free in September More cases were discovered in November On January 14,Liberia again announced it was Ebola-free; however, cases were detected in March and April ofand Liberia made its final declaration on June 1, In Guinea, the first end of outbreak declaration was in Decemberbut additional cases were discovered in March and April of Guinea was finally declared Ebola-free in June Overall, eleven people were treated for Ebola in the United States during the epidemic.

The patient the index case died on October 8, Two healthcare workers who cared for him in Dallas tested positive for EVD. Both recovered. The diagnosis was confirmed by the CDC the next day. The patient recovered.

Seven other people were cared for in the United States after they were exposed to the virus and became ill while in West Africa, the majority of whom were medical workers. They were transported by chartered aircraft from West Africa to hospitals in the United States. Six of these patients recovered, one died. CDC activated its Emergency Operations Center in July to help coordinate technical assistance and disease control activities with partners.

CDC personnel deployed to West Africa to assist with response efforts, including surveillance, contact tracing, data management, laboratory testing, and health education. CDC staff also provided support with logistics, staffing, communication, analytics, and management. To prevent cross-border transmission, travelers leaving West Africa were screened at airports.

Exit screening helped identify those at risk for EVD and prevent the spread of the disease to other countries. The United States also implemented enhanced entry screening for travelers coming from Guinea, Liberia, Sierra Leone, and Mali by routing them to designated airports better able to assess travelers for risk.

During the height of the response, CDC trained 24, healthcare workers in West Africa on infection prevention and control practices. In addition, laboratory capacity was expanded in Guinea, Liberia, and Sierra Leone with 24 laboratories able to test for Ebola virus by the end of The impact this epidemic had on the world, and particularly West Africa, is significant.

There were an additional 36 cases and 15 deaths that occurred when the outbreak spread outside of these three countries. The table below shows the distribution of cases and deaths in countries with widespread transmission and countries affected by the epidemic. Graphs of reported casescalled epidemic curves, show the rate incidence of new, probable, and confirmed cases over the duration of the outbreak in the three West African countries with widespread transmission, Guinea, Liberia, and Sierra Leone.

Healthcare workers caring for patients with EVD were among those at highest risk for contracting the disease. The epidemic also had a great impact on children.Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

A Nature Research Journal.

2014 New Hampshire gubernatorial election

Acute erythroid leukemia AEL is a high-risk leukemia of poorly understood genetic basis, with controversy regarding diagnosis in the spectrum of myelodysplasia and myeloid leukemia.

This genomic landscape of AEL provides the framework for accurate diagnosis and risk stratification of this disease, and the rationale for testing targeted therapies in this high-risk leukemia. Moreover, genomic data including nonsilent SNV, indels, ITD sequence mutations, in-frame gene fusions, structural variations, copy number aberrations and gene expression data can be explored interactively at the St.

Cancer Genome Atlas Research Network Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. Google Scholar. Papaemmanuil, E. Genomic classification and prognosis in acute myeloid leukemia. Cervera, N. Molecular characterization of acute erythroid leukemia M6-AML using targeted next-generation sequencing. Leukemia 30— Grossmann, V. Acute erythroid leukemia AEL can be separated into distinct prognostic subsets based on cytogenetic and molecular genetic characteristics.

Leukemia 27— Ping, N. Leukemia 31— Liu, W. Pure erythroid leukemia: a reassessment of the entity using the World Health Organization classification. Almeida, A. Clinical outcomes of patients with acute erythroleukemia according to treatment type and line: a retrospective multinational study. Dameshek, W.Take advantage of your membership privileges! Extra savings for Volleyball BC members at belairdirect! Volleyball BC members and their families can benefit from an exclusive discount on their car, home, condo and tenants insurance, on top of any other discounts, savings and benefits customers are already eligible for at belairdirect.

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n)?h ) ael 28 mar, 2914

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Volleyball BC. Published on Apr 20, Welcome to NHL. Vitajte na NHL. Willkommen auf NHL. Bienvenido a NHL. Ovechkin was the first player taken in the NHL Draft and made an immediate impact in his first season by scoring 52 goals and points inearning him the Calder Trophy as the NHL's top rookie. His 65 goals in are the most by any player in the 21st century, and he reached the goal mark for the eighth time, the most among active players, when he scored 51 times in Ovechkin scored his th NHL goal on Jan.

Crosby won the Stanley Cup for the third time, and for the second straight season, in Crosby, the No. The Oilers took McDavid with the No. McDavid took his game to another level inleading the NHL with points 30 goals, 70 assistswinning the Hart Trophy as most valuable player and the Ted Lindsay Award for the most outstanding player, and helping the Oilers reach the Stanley Cup Playoffs for the first time since McDavid led the NHL in scoring again in with points 41 goals, 67 assistsand won the Ted Lindsay Award for the second straight year.

Matthews is one of those rare players who is living up to the hype that preceded him into the NHL. Selected by the Maple Leafs with the No.

He led all rookies in goals 40 and points 69 inwon the Calder Trophy, voted to the NHL's rookie of the year, and helped the Maple Leafs advance to the Stanley Cup Playoffs for the second time since Matthews had 63 points 34 goals, 29 assists in 62 games inthen began by becoming the fifth player in NHL history to have multiple points in each of his team's first seven games. That came after he spent the first nine seasons of his career with the New York Islanders, who selected him with the No. He was also voted a First-Team All-Star inbecoming the first Islanders player to earn that honor since Mike Bossy in Tavares had 84 points inthe third point season of his NHL career, and he had an NHL career-high 47 goals in his first season with Toronto.

Laine, selected by the Jets with the No. He then wasted little time showing that his skills translated well to the smaller NHL rinks, becoming a threat to score any time he stepped on the ice. Laine finished with 64 points 36 goals, 28 assists in 73 games, finishing second in voting for the Calder Trophy as the NHL's top rookie.

He was even better in his second season, finishing second in the NHL with 44 goals, then had 12 points five goals, seven assists in 17 Stanley Cup Playoff games to help the Jets advance to the Western Conference Final before losing to the Vegas Golden Knights. Laine had his third straight goal season in Kane's overtime goal in Game 6 of the Final gave the Blackhawks their first Stanley Cup championship in 49 years.